Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.67 |
| ▸ | MMP13 | P45452 | 12/20 | 0.46 |
| ▸ | MMP2 | P08253 | 10/20 | 0.46 |
| ▸ | MMP8 | P22894 | 9/20 | 0.46 |
| ▸ | MMP9 | P14780 | 9/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | MMP14 | P50281 | 7/20 | 0.43 |
| ▸ | MMP3 | P08254 | 6/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307897 | 0.80 | MMP1 (1.00) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL7302803 | 0.80 | MMP1 (0.83) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL7302762 | 0.79 | MMP1 (0.81) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL4314591 | 0.79 | MMP1 (1.00) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL8334607 | 0.74 | MMP13 (0.67) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL7311267 | 0.74 | MMP1 (0.73) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL6823262 | 0.73 | MMP1 (0.59) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL7301387 | 0.73 | MMP1 (0.79) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL7309090 | 0.71 | MMP1 (0.80) | MMP1MMP13MMP2MMP8MMP9 | |
| SCHEMBL5919453 | 0.71 | MMP13 (0.62) | MMP1MMP13MMP2MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |