Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.62 |
| ▸ | MMP2 | P08253 | 12/20 | 0.62 |
| ▸ | MMP3 | P08254 | 6/20 | 0.62 |
| ▸ | PDE4A | P27815 | 6/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.62 |
| ▸ | MMP13 | P45452 | 9/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311602 | 0.92 | MMP1 (0.62) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7305191 | 0.91 | MMP1 (0.76) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7302387 | 0.90 | MMP2 (0.60) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7301051 | 0.87 | MMP1 (0.57) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7308096 | 0.87 | MMP1 (0.57) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7301418 | 0.85 | PDE4A (0.61) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7308283 | 0.85 | MMP1 (0.80) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6823613 | 0.80 | MMP2 (0.87) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7311001 | 0.80 | PDE4A (0.56) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6824624 | 0.77 | MMP2 (1.00) | MMP1MMP2MMP3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |