Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311878 | 0.97 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1NPSR1CTSK | |
| SCHEMBL7311871 | 0.97 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1NPSR1CTSK | |
| SCHEMBL7311882 | 0.97 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1NPSR1CTSK | |
| SCHEMBL31630289 | 0.84 | MMP2 (0.43) | SMN1; SMN2CTSKDDB1CRBNMMP2 | |
| SCHEMBL7305924 | 0.80 | CTSK (0.43) | SMN1; SMN2KMT2AMEN1NPSR1CTSK | |
| SCHEMBL31630212 | 0.80 | TSHR (0.43) | SMN1; SMN2KMT2AMEN1CTSKDDB1 | |
| SCHEMBL31629893 | 0.80 | TSHR (0.43) | SMN1; SMN2KMT2AMEN1CTSKDDB1 | |
| SCHEMBL9380229 | 0.79 | ALDH1A1 (0.45) | SMN1; SMN2KMT2ACTSKDDB1CRBN | |
| SCHEMBL10943286 | 0.79 | CTSK (0.50) | SMN1; SMN2KMT2AMEN1NPSR1CTSK | |
| SCHEMBL10943291 | 0.79 | CTSK (0.50) | SMN1; SMN2KMT2AMEN1NPSR1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |