Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.41 |
| ▸ | F2 | P00734 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309074 | 1.00 | ACE (0.41) | ACEF2KDM4EPRSS1RECQL | |
| SCHEMBL8083547 | 0.93 | TACR1 (0.44) | ACEF2PRSS1DPP4DPP8 | |
| SCHEMBL7308390 | 0.93 | TACR1 (0.44) | ACEF2PRSS1DPP4DPP8 | |
| SCHEMBL7308379 | 0.93 | TACR1 (0.44) | ACEF2PRSS1DPP4DPP8 | |
| SCHEMBL7316690 | 0.88 | F2 (0.42) | ACEF2PRSS1FKBP1ADPP4 | |
| SCHEMBL7316700 | 0.88 | F2 (0.42) | ACEF2PRSS1FKBP1ADPP4 | |
| SCHEMBL7307561 | 0.88 | ACE (0.38) | ACEF2PRSS1DPP4ACE2 | |
| SCHEMBL7306120 | 0.87 | ACE (0.48) | ACEDPP4DPP8CHRM3ACE2 | |
| SCHEMBL7306125 | 0.87 | ACE (0.48) | ACEDPP4DPP8CHRM3ACE2 | |
| SCHEMBL7307838 | 0.87 | F2 (0.47) | ACEF2ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041064-A2 | N-substituted alpha aminoacid amides as calcium channel modulators | ELI LILLY AND COMPANY LIMITED (GB) | 2000-10-04 | — | — | EP | disclosed |
| EP-0805147-A1 | Novel N-substituted alpha aminoacid amides as calcium channel modulators | LILLY INDUSTRIES LIMITED (GB) | 1997-11-05 | — | — | EP | disclosed |