Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 4/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083547 | 0.88 | TACR1 (0.44) | ACEF2PRSS1DPP4 | |
| SCHEMBL7309074 | 0.88 | ACE (0.41) | ACEACE2F2PRSS1DPP4 | |
| SCHEMBL7309067 | 0.88 | ACE (0.41) | ACEACE2F2PRSS1DPP4 | |
| SCHEMBL7308379 | 0.88 | TACR1 (0.44) | ACEF2PRSS1DPP4 | |
| SCHEMBL7308390 | 0.88 | TACR1 (0.44) | ACEF2PRSS1DPP4 | |
| SCHEMBL7308426 | 0.88 | ACE (0.46) | ACEACE2LMNA | |
| SCHEMBL7308435 | 0.88 | ACE (0.46) | ACEACE2LMNA | |
| SCHEMBL7316690 | 0.83 | F2 (0.42) | ACEF2KMT2APRSS1DPP4 | |
| SCHEMBL7316700 | 0.83 | F2 (0.42) | ACEF2KMT2APRSS1DPP4 | |
| SCHEMBL7306120 | 0.82 | ACE (0.48) | ACEACE2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041064-A2 | N-substituted alpha aminoacid amides as calcium channel modulators | ELI LILLY AND COMPANY LIMITED (GB) | 2000-10-04 | — | — | EP | disclosed |
| EP-0805147-A1 | Novel N-substituted alpha aminoacid amides as calcium channel modulators | LILLY INDUSTRIES LIMITED (GB) | 1997-11-05 | — | — | EP | disclosed |