Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 4/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 18/20 | 1.00 |
| ▸ | KLK1 | P06870 | 5/20 | 1.00 |
| ▸ | TMPRSS15 | P98073 | 13/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569896 | 1.00 | PRSS1 (1.00) | PRSS1KLK1F2TMPRSS15FTO | |
| SCHEMBL5574445 | 1.00 | PRSS1 (1.00) | PRSS1KLK1F2TMPRSS15FTO | |
| SCHEMBL3238554 | 0.95 | PRSS1 (1.00) | PRSS1KLK1F2TMPRSS15 | |
| SCHEMBL7314190 | 0.95 | PRSS1 (1.00) | PRSS1KLK1F2TMPRSS15 | |
| SCHEMBL1650235 | 0.91 | PRSS1 (1.00) | PRSS1KLK1F2TMPRSS15FTO | |
| SCHEMBL7189652 | 0.90 | PRSS1 (0.88) | PRSS1KLK1F2TMPRSS15 | |
| SCHEMBL7189654 | 0.90 | PRSS1 (0.88) | PRSS1KLK1F2TMPRSS15 | |
| SCHEMBL7304798 | 0.90 | PRSS1 (0.81) | PRSS1KLK1F2TMPRSS15 | |
| SCHEMBL7309079 | 0.89 | PRSS1 (0.81) | PRSS1KLK1F2TMPRSS15FTO | |
| SCHEMBL3239747 | 0.88 | PRSS1 (0.82) | PRSS1KLK1F2TMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614555-A | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0588655-B1 | Amidinophenol derivatives | ONO PHARMACEUTICAL CO (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5432178-A | Substituted benzoic acid esters; use to prevent or treat inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis or multiple organ failure | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-11 | — | — | US | disclosed |
| EP-0588655-A1 | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |