Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309224 | 1.00 | PPARA (0.55) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL1541597 | 0.90 | CASP1 (0.62) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL4973400 | 0.90 | CASP1 (0.62) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL6487973 | 0.90 | CASP1 (0.62) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL7810073 | 0.89 | CASP1 (0.61) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL7810068 | 0.89 | CASP1 (0.61) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL5226937 | 0.86 | PPARA (0.55) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL7302654 | 0.85 | CA2 (0.52) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL7302646 | 0.85 | CA2 (0.52) | PPARAPPARGMMP13CASP1CTSK | |
| SCHEMBL23927277 | 0.81 | PPARA (0.73) | PPARAPPARGCASP1CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |