Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.32 |
| ▸ | CD38 | P28907 | 5/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299247 | 0.79 | LTA4H (0.41) | NPC1RAB9ALTA4HKDM4EALDH1A1 | |
| SCHEMBL7309529 | 0.76 | DYRK1A (0.37) | DYRK1AHDAC4DYRK2DYRK1BCARM1 | |
| SCHEMBL9672822 | 0.76 | GSTP1 (0.37) | NPC1RAB9ALTA4HALDH1A1LMNA | |
| SCHEMBL6448261 | 0.72 | NOTUM (0.33) | LTA4HKDM4ELMNASMN1; SMN2MAPT | |
| SCHEMBL8535180 | 0.71 | LTA4H (0.52) | NPC1RAB9ALTA4H | |
| SCHEMBL48894 | 0.71 | DYRK1A (0.55) | DYRK1AHDAC4DYRK2DYRK1BCD38 | |
| SCHEMBL76698 | 0.71 | LTA4H (0.50) | LTA4HKDM4ELMNAMAPT | |
| SCHEMBL7300800 | 0.71 | CYP2A6 (0.48) | LTA4H | |
| SCHEMBL4531816 | 0.71 | KDM4E (0.37) | DYRK1AHDAC4DYRK2DYRK1BCD38 | |
| SCHEMBL28770243 | 0.69 | LTA4H (0.48) | LTA4HKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |