Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 16/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307656 | 0.99 | PARP1 (0.63) | PARP1CYP1A2CYP3A4HTR1AMAPT | |
| Bromide SCHEMBL7301782 | 0.92 | PARP1 (0.62) | PARP1CYP1A2CYP3A4HTR1AMAPT | |
| Bromide SCHEMBL7303725 | 0.89 | PARP1 (0.63) | PARP1CYP1A2CYP3A4HTR1AMAPT | |
| SCHEMBL7303316 | 0.88 | PARP1 (0.64) | PARP1CYP1A2CYP3A4HTR1AMAPT | |
| SCHEMBL7302855 | 0.87 | PARP1 (0.64) | PARP1DRD2 | |
| SCHEMBL7305161 | 0.87 | PARP1 (0.73) | PARP1 | |
| Hydrochloric Acid SCHEMBL7301868 | 0.86 | PARP1 (0.62) | PARP1MAPT | |
| SCHEMBL7303980 | 0.85 | PARP1 (0.60) | PARP1HTR1AMAPT | |
| SCHEMBL7301646 | 0.84 | PARP1 (0.59) | PARP1 | |
| SCHEMBL7307836 | 0.83 | PARP1 (0.58) | PARP1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |