Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meluadrine SCHEMBL250026 | 0.88 | ADRB2 (0.65) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Meluadrine SCHEMBL29508537 | 0.88 | ADRB2 (0.65) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Meluadrine SCHEMBL120043 | 0.88 | ADRB2 (0.65) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Meluadrine SCHEMBL7317575 | 0.81 | ADRB2 (0.57) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Meluadrine SCHEMBL123344 | 0.79 | ADRB2 (0.55) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Meluadrine SCHEMBL1650082 | 0.79 | ADRB2 (0.55) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Meluadrine SCHEMBL30591457 | 0.79 | ADRB2 (0.55) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Tulobuterol SCHEMBL122692 | 0.79 | ADRB2 (1.00) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Tulobuterol SCHEMBL29866527 | 0.79 | ADRB2 (1.00) | ADRB2HIF1AADRB1CYP2D6NFKB1 | |
| Tulobuterol SCHEMBL30986127 | 0.79 | ADRB2 (1.00) | ADRB2HIF1AADRB1CYP2D6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4018818-A | Hydroxyl-substituted 2-chloro-α-(tert-butylaminomethyl)-benzylalcohols | HOKURIKU PHARMACEUTICAL CO., LTD. (JA) | 1977-04-19 | — | — | US | disclosed |