Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27741084 | 0.98 | NPC1 (0.55) | KMT2AMEN1KDM4ENPC1L3MBTL1 | |
| SCHEMBL5363594 | 0.84 | HTR3A (0.73) | DRD2DRD3MAPTHTR3AHTR3E | |
| SCHEMBL29786229 | 0.84 | HTR3A (0.73) | DRD2DRD3MAPTHTR3AHTR3E | |
| SCHEMBL7491552 | 0.83 | KDM4E (0.49) | KMT2AMEN1KDM4EDRD2DRD3 | |
| SCHEMBL28757966 | 0.82 | KMT2A (0.44) | KMT2AMEN1KDM4ENPC1L3MBTL1 | |
| SCHEMBL3165674 | 0.82 | DRD2 (0.72) | NPC1RAB9ADRD2DRD3MAPT | |
| SCHEMBL12806146 | 0.81 | USP2 (0.54) | KMT2AMEN1KDM4EDRD2DRD3 | |
| SCHEMBL8339929 | 0.81 | HTR2A (0.46) | KMT2AMEN1L3MBTL1DRD2MAPT | |
| SCHEMBL3020451 | 0.81 | DRD2 (0.70) | NPC1L3MBTL1RAB9ADRD2DRD3 | |
| SCHEMBL3174809 | 0.81 | DRD2 (0.70) | NPC1L3MBTL1RAB9ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| EP-0360685-B1 | 1-[(Diaryl methoxy)alkyl] pyrrolidines and piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA (FR) | 1994-02-02 | — | — | EP | disclosed |
| EP-0360685-A1 | 1-[(Diaryl methoxy)alkyl] pyrrolidines and piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-03-28 | — | — | EP | disclosed |