⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27723749 | 0.54 | TSHR (0.41) | — | |
| SCHEMBL819903 | 0.51 | CCR2 (0.35) | — | |
| SCHEMBL17159758 | 0.48 | TSHR (0.35) | — | |
| SCHEMBL1355431 | 0.48 | TSHR (0.37) | — | |
| SCHEMBL19750859 | 0.48 | TSHR (0.35) | — | |
| SCHEMBL813574 | 0.48 | TSHR (0.35) | — | |
| SCHEMBL10964095 | 0.48 | ALOX15 (0.36) | — | |
| SCHEMBL813575 | 0.48 | TSHR (0.35) | — | |
| SCHEMBL22362544 | 0.48 | TSHR (0.35) | — | |
| SCHEMBL31091494 | 0.47 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5596012-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1997-01-21 | — | — | US | claimed |
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |
| US-5650422-A | TREATMENT OF EMPHYSEMA, ARTHRITIS OR PANCREATITIS | SANOFI (FR) | 1997-07-22 | — | — | US | disclosed |
| US-5596012-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5236917-A | Respiratory system disorders, antiarthritic agents | STERLING WINTHROP INC. (US) | 1993-08-17 | — | — | US | disclosed |