SCHEMBL7310561

SCHEMBL7310561

O=C(NO)C(CSc1ccccc1)Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.56
MMP9 P14780 2/20 0.56
MMP1 P03956 2/20 0.51
FCER2 P06734 2/20 0.51
ADAM17 P78536 1/20 0.51
CYP1A2 P05177 1/20 0.49
HDAC1 Q13547 3/20 0.48
HDAC3 O15379 2/20 0.48
HDAC8 Q9BY41 2/20 0.48
HDAC6 Q9UBN7 1/20 0.48
MMP8 P22894 2/20 0.48
MME P08473 3/20 0.47
HDAC4 P56524 1/20 0.46
HDAC2 Q92769 1/20 0.46
MTNR1A P48039 3/20 0.45
MTNR1B P49286 3/20 0.45
LTA4H P09960 1/20 0.45
ANPEP P15144 1/20 0.45
ECE1 P42892 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7308337 0.87 MMP9 (0.55) MMP2MMP9MMP1FCER2ADAM17
SCHEMBL7303001 0.84 MTNR1A (0.54) MMP2MMP9MMP1MTNR1AMTNR1B
SCHEMBL13103439 0.83 CYP1A2 (0.63) CYP1A2HDAC1HDAC3HDAC8HDAC6
SCHEMBL7302563 0.79 MMP2 (0.47) MMP2MMP9MMP1FCER2ADAM17
SCHEMBL7392419 0.78 HDAC8 (0.54) MMP2MMP9MMP1HDAC1HDAC3
SCHEMBL13103425 0.77 CYP1A2 (0.60) CYP1A2HDAC1HDAC3HDAC8HDAC6
SCHEMBL7356639 0.77 HDAC8 (0.56) MMP2MMP9MMP1HDAC1HDAC3
SCHEMBL23190984 0.74 MMP2 (0.56) MMP2MMP9MMP1CYP1A2MMP8
SCHEMBL6170034 0.74 CYP1A2 (0.53) CYP1A2
SCHEMBL6170039 0.74 CYP1A2 (0.53) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0780386-B1 Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5932595-A ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT SYNTEX (U.S.A.) INC. (US) 1999-08-03 US disclosed
EP-0780386-A1 Matrix metalloprotease inhibitors F. HOFFMANN-LA ROCHE AG (CH) 1997-06-25 EP disclosed