Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 12/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302660 | 0.84 | KLK5 (0.51) | CTSSCTSKKLK5 | |
| SCHEMBL8955018 | 0.84 | KLK5 (0.46) | LMNAKLK5 | |
| SCHEMBL7307304 | 0.83 | KLK5 (0.52) | KLK5 | |
| SCHEMBL7314764 | 0.83 | KLK5 (0.52) | KLK5 | |
| SCHEMBL8955028 | 0.82 | KLK5 (0.52) | KMT2ALMNAMEN1KLK5 | |
| SCHEMBL7309371 | 0.82 | KLK5 (0.46) | KLK5 | |
| SCHEMBL7312642 | 0.82 | KLK5 (0.52) | LTA4HKLK5 | |
| SCHEMBL8955074 | 0.81 | BACE1 (0.44) | KLK5 | |
| SCHEMBL7311526 | 0.81 | KLK5 (0.55) | KLK5 | |
| SCHEMBL7303561 | 0.81 | KLK5 (0.61) | CTSSCTSKKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559256-A | Aminediol protease inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0580402-A2 | Aminediol protease inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1994-01-26 | — | — | EP | disclosed |