Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319935 | 0.93 | NAMPT (0.48) | NAMPTMMP9MMP1MMP13KEAP1 | |
| SCHEMBL7311857 | 0.92 | NAMPT (0.46) | NAMPTMMP9MMP1MMP13KEAP1 | |
| SCHEMBL7354595 | 0.92 | MMP9 (0.48) | NAMPTMMP9MMP1MMP13KEAP1 | |
| SCHEMBL7324058 | 0.92 | NAMPT (0.49) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7323477 | 0.90 | NAMPT (0.44) | NAMPTMMP9MMP1MMP13KEAP1 | |
| SCHEMBL7321756 | 0.90 | MMP13 (0.50) | NAMPTMMP9MMP1MMP13GAA | |
| SCHEMBL7322659 | 0.89 | MMP2 (0.47) | MMP9MMP1MMP13ALDH1A1MMP2 | |
| SCHEMBL7319594 | 0.87 | NAMPT (0.42) | NAMPTMMP9MMP1MMP13KEAP1 | |
| SCHEMBL7317088 | 0.86 | NAMPT (0.42) | NAMPTMMP9MMP1MMP13KEAP1 | |
| SCHEMBL7352965 | 0.86 | MMP9 (0.44) | NAMPTMMP9MMP1MMP13KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |