Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 14/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315986 | 0.89 | ADRB3 (0.62) | ADRB3ADRB1ADRB2KMT2AMEN1 | |
| SCHEMBL7317757 | 0.86 | ADRB2 (0.68) | ADRB3ADRB1ADRB2KMT2AALDH1A1 | |
| SCHEMBL7315722 | 0.82 | CASR (0.59) | ADRB3ADRB2 | |
| SCHEMBL7306021 | 0.82 | ADRB2 (0.54) | ADRB3ADRB1ADRB2KMT2AALDH1A1 | |
| SCHEMBL7306704 | 0.81 | CYP2D6 (0.62) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7310724 | 0.81 | CYP2D6 (0.56) | ADRB3ADRB1ADRB2KMT2AMEN1 | |
| SCHEMBL27478454 | 0.80 | ADRB1 (0.78) | ADRB3ADRB1ADRB2KMT2AALDH1A1 | |
| SCHEMBL11513676 | 0.79 | CYP2D6 (0.50) | ADRB3ADRB1ADRB2KMT2AALDH1A1 | |
| SCHEMBL15275450 | 0.77 | ADRB3 (0.76) | ADRB3ADRB1ADRB2KMT2AMEN1 | |
| SCHEMBL7319028 | 0.77 | ADRB2 (0.56) | ADRB3ADRB1ADRB2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4171370-A | Phenoxy-amino-propanols | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-10-16 | — | — | US | disclosed |