Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298900 | 0.85 | MMP1 (0.48) | MTNR1AMTNR1BCA1CA2NPC1 | |
| SCHEMBL727827 | 0.80 | CA1 (0.43) | MTNR1AMTNR1BALDH1A1CA1CA2 | |
| SCHEMBL1140787 | 0.79 | ALDH1A1 (0.43) | MTNR1AMTNR1BALDH1A1CA1CA2 | |
| SCHEMBL7862221 | 0.78 | ALDH1A1 (0.61) | MTNR1AMTNR1BALDH1A1NPC1RAB9A | |
| SCHEMBL7305756 | 0.73 | ALDH1A1 (0.54) | ALDH1A1CA1CA2SMN1; SMN2KMT2A | |
| SCHEMBL27891586 | 0.73 | CA12 (0.42) | MTNR1AMTNR1BALDH1A1CA1CA2 | |
| SCHEMBL13210450 | 0.71 | CA1 (0.44) | MTNR1AMTNR1BALDH1A1CA1CA2 | |
| SCHEMBL7312224 | 0.70 | ADAM17 (0.48) | MTNR1AMTNR1BALDH1A1CA1CA2 | |
| SCHEMBL7311896 | 0.69 | MMP1 (0.50) | ALDH1A1TDP1L3MBTL1MAPTKMT2A | |
| SCHEMBL7304806 | 0.69 | PPARG (0.44) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |