Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.53 |
| ▸ | PDE4A | P27815 | 13/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7387770 | 0.99 | ALOX15 (0.53) | ALOX15ACHEPDE4DPDE4APDE4B | |
| SCHEMBL7316969 | 0.85 | PDE4A (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL9275364 | 0.82 | ALDH1A1 (0.56) | ALOX15PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7390993 | 0.81 | PDE4A (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6889304 | 0.81 | PDE4A (0.63) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7388392 | 0.81 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL8688573 | 0.80 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6887553 | 0.80 | PDE4A (0.62) | PDE4DPDE4APDE4BPDE4C | |
| Methyl Alcohol SCHEMBL7418694 | 0.80 | PDE4B (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7341287 | 0.80 | PDE4A (0.62) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | claimed |
| EP-0640065-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2001-10-17 | — | — | EP | disclosed |
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5780478-A | Tetra-substituted phenyl derivatives | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |