Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367121 | 0.92 | CACNA1B (0.44) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10368966 | 0.88 | LMNA (0.38) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30358017 | 0.88 | CYP1A2 (0.65) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7308471 | 0.88 | CYP1A2 (0.65) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7307501 | 0.85 | CACNA1B (0.42) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7314526 | 0.83 | CYP2C9 (0.52) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10999226 | 0.83 | ADORA3 (0.43) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7320393 | 0.82 | CYP1A2 (0.57) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7309693 | 0.82 | CYP1A2 (0.61) | LMNAADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7314717 | 0.82 | CYP1A2 (0.57) | LMNAADORA3CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177965-B1 | NOVEL OXA- AND THIADIAZOLYL DERIVATIVES AND THEIR USE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-03-21 | — | — | EP | claimed |
| US-4705786-A | Novel oxadiazolyl-1,4-dihydropyridines useful as antihypertensive agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-11-10 | — | — | US | claimed |
| EP-0177965-A2 | Novel oxa- and thiadiazolyl derivatives and their use | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1986-04-16 | — | — | EP | claimed |