Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.62 |
| ▸ | MIF | P14174 | 4/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.56 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DDT | P30046 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71676 | 0.87 | RIPK1 (0.49) | RIPK1MIFEGLN1ACKR3ALDH1A1 | |
| SCHEMBL17883253 | 0.82 | RIPK1 (0.58) | RIPK1MIFESRRAACKR3NOTUM | |
| SCHEMBL17883261 | 0.81 | RIPK1 (0.63) | RIPK1MIFESRRAACKR3ALDH1A1 | |
| SCHEMBL30009481 | 0.81 | RIPK1 (0.63) | RIPK1MIFESRRAACKR3NOTUM | |
| SCHEMBL17883296 | 0.81 | RIPK1 (0.63) | RIPK1MIFESRRAACKR3L3MBTL1 | |
| SCHEMBL69876 | 0.77 | ESRRA (0.62) | RIPK1MIFESRRANOTUML3MBTL1 | |
| SCHEMBL27768462 | 0.77 | ESRRA (0.71) | RIPK1ESRRANOTUML3MBTL1 | |
| SCHEMBL12450543 | 0.76 | MIF (0.71) | RIPK1MIFACKR3ALDH1A1DDT | |
| SCHEMBL12522014 | 0.76 | MIF (0.77) | RIPK1MIFACKR3ALDH1A1LMNA | |
| SCHEMBL18747441 | 0.76 | MIF (0.73) | RIPK1MIFACKR3ALDH1A1DDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129376-B2 | Piperidine derivatives as inhibitors of stearoyl-CoA desaturase | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-03-06 | — | — | US | disclosed |
| CN-102036558-A | Novel piperidine derivatives as stearoyl-CoA desaturase inhibitors | FOREST LAB HOLDINGS LTD | 2011-04-27 | — | — | CN | disclosed |
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | US | disclosed |
| WO-2009117676-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | RIPK1 1678/4885MIF 4662/4885EGLN1 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.