Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.34 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312745 | 0.75 | HPGD (0.45) | HPGDCSNK1DALDH1A1HSD17B10MAPK1 | |
| SCHEMBL7319490 | 0.73 | MEN1 (0.46) | KMT2AHPGDCSNK1DPIK3CAMTOR | |
| SCHEMBL7316090 | 0.67 | HPGD (0.38) | HPGDCSNK1DKDM4E | |
| SCHEMBL7316083 | 0.66 | KDM4E (0.46) | HPGDPIK3CAMTORALDH1A1HSD17B10 | |
| SCHEMBL8987525 | 0.64 | MAPK13 (0.38) | POLBRAD52SMARCA2KMT2AUHRF1 | |
| SCHEMBL7308816 | 0.62 | KDR (0.39) | HPGDPIK3CAMTORALDH1A1HSD17B10 | |
| SCHEMBL29056666 | 0.61 | DRD3 (0.68) | POLBKMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL31194631 | 0.61 | ADORA3 (0.48) | POLBKMT2AKDM4EMAPK1 | |
| SCHEMBL10369151 | 0.60 | SLC6A4 (0.47) | POLBRAD52SMARCA2KMT2AUHRF1 | |
| SCHEMBL10367589 | 0.60 | TOP2A (0.39) | POLBRAD52KMT2AUHRF1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |