Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460756 | 0.83 | KDM4E (0.43) | RAD52KDM4EMAPTGAATHRB | |
| SCHEMBL22418957 | 0.81 | ALDH1A1 (0.43) | ALDH1A1CYP3A4TDP1TSHRAPP | |
| SCHEMBL7309063 | 0.80 | HPGD (0.39) | NR3C1NR3C2HPGDSMN1; SMN2HSD11B1 | |
| SCHEMBL10901975 | 0.78 | NR3C1 (0.39) | KDM4EMAPTGAAALDH1A1NR3C1 | |
| SCHEMBL30242191 | 0.78 | ALDH1A1 (0.46) | MAPTGAATHRBALDH1A1CYP3A4 | |
| SCHEMBL28980278 | 0.78 | ALDH1A1 (0.46) | MAPTGAATHRBALDH1A1CYP3A4 | |
| SCHEMBL17580580 | 0.77 | TLR8 (0.35) | NR3C1NR3C2MCL1HSD11B1 | |
| SCHEMBL10680998 | 0.77 | TUBB4A (0.33) | KDM4ETSHRNR3C1NR3C2MEN1 | |
| SCHEMBL25092810 | 0.76 | TSHR (0.37) | KDM4EMAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL30242192 | 0.76 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4783467-A | Tetrahydroimidazoquinazolinone inotropic agents | PFIZER INC. (US) | 1988-11-08 | — | — | US | disclosed |
| US-4740513-A | CARDIAC STIMULANTS | PFIZER INC. (US) | 1988-04-26 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0226357-A1 | Quinolone cardiac stimulants | Pfizer Limited (GB) | 1987-06-24 | — | — | EP | disclosed |
| EP-0205280-A2 | Tetrahydroimidazoquinazolinone cardiac stimulants | Pfizer Limited (GB) | 1986-12-17 | — | — | EP | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |