Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.65 |
| ▸ | MMP13 | P45452 | 14/20 | 0.65 |
| ▸ | MMP8 | P22894 | 2/20 | 0.65 |
| ▸ | MMP2 | P08253 | 1/20 | 0.65 |
| ▸ | MMP1 | P03956 | 10/20 | 0.52 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067889 | 0.81 | ADAM17 (0.73) | ADAM17MMP13MMP8MMP2 | |
| SCHEMBL8334567 | 0.81 | ADAM17 (0.77) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL8335658 | 0.80 | ADAM17 (0.68) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL12708189 | 0.79 | ADAM17 (1.00) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL8334970 | 0.79 | ADAM17 (1.00) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL8329165 | 0.79 | ADAM17 (1.00) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL6628715 | 0.77 | ADAM17 (0.62) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL8334839 | 0.77 | ADAM17 (1.00) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL6660993 | 0.74 | ADAM17 (0.49) | ADAM17MMP13MMP8MMP2MMP1 | |
| SCHEMBL6263837 | 0.73 | ADAM17 (0.64) | ADAM17MMP13MMP8MMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |