Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.49 |
| ▸ | MMP13 | P45452 | 9/20 | 0.49 |
| ▸ | MMP1 | P03956 | 4/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657000 | 0.84 | ADAM17 (0.49) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6934597 | 0.76 | ADAM17 (0.50) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL7313611 | 0.74 | ADAM17 (0.65) | ADAM17MMP13MMP1MMP9MMP2 | |
| Hydroxyamine SCHEMBL7463488 | 0.71 | S1PR5 (0.52) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6865929 | 0.71 | ADAM17 (0.53) | ADAM17MMP13MMP1MMP9 | |
| Hydroxyamine SCHEMBL6861859 | 0.71 | ADAM17 (0.52) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL7512543 | 0.71 | TAS2R14 (0.50) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6757626 | 0.70 | ADAM17 (0.47) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL7580801 | 0.70 | MMP9 (0.48) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL7511310 | 0.69 | MMP1 (0.50) | ADAM17MMP13MMP1MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |