Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20472424 | 0.84 | XDH (0.50) | XDHGPR6MKNK1MKNK2CHEK1 | |
| SCHEMBL21191760 | 0.81 | CHRNB2 (0.52) | MKNK1MKNK2CHEK1IKBKBCHUK | |
| SCHEMBL10369852 | 0.80 | HRH3 (0.43) | GPR6 | |
| SCHEMBL29844280 | 0.76 | KDM4E (0.47) | XDHGPR6 | |
| SCHEMBL25221184 | 0.76 | MKNK1 (0.45) | MKNK1MKNK2IKBKBCHUKMELK | |
| SCHEMBL31165733 | 0.76 | MKNK1 (0.45) | MKNK1MKNK2IKBKBCHUKMELK | |
| SCHEMBL21179334 | 0.75 | GPR6 (0.41) | GPR6ELANEIKBKBCHUK | |
| SCHEMBL21179390 | 0.75 | GPR6 (0.41) | GPR6ELANEIKBKBCHUK | |
| SCHEMBL25221956 | 0.75 | IKBKB (0.48) | MKNK1MKNK2IKBKBCHUKMELK | |
| SCHEMBL24247772 | 0.74 | GPR6 (0.40) | XDHGPR6ALDH1A1SMN1; SMN2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |