Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 18/20 | 0.59 |
| ▸ | MMP13 | P45452 | 17/20 | 0.59 |
| ▸ | MMP1 | P03956 | 16/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27511016 | 0.95 | MMP9 (0.53) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7316636 | 0.91 | MMP9 (0.73) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7316221 | 0.84 | MMP1 (0.81) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7447117 | 0.83 | MMP9 (0.77) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7316352 | 0.79 | MMP9 (0.59) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7323227 | 0.76 | MMP1 (0.82) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL28744402 | 0.76 | MMP1 (0.68) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL7817619 | 0.75 | MMP1 (0.61) | MMP9MMP13MMP1ADAM17HTR6 | |
| SCHEMBL27533470 | 0.74 | MMP9 (0.63) | MMP9MMP13MMP1ADAM17LMNA | |
| SCHEMBL6852400 | 0.74 | MMP9 (1.00) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |