Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.81 |
| ▸ | MMP9 | P14780 | 15/20 | 0.81 |
| ▸ | MMP13 | P45452 | 15/20 | 0.81 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.81 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323227 | 0.91 | MMP1 (0.82) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL28744402 | 0.91 | MMP1 (0.68) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL6852400 | 0.89 | MMP9 (1.00) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7313719 | 0.84 | MMP9 (0.59) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL27511019 | 0.81 | KEAP1 (0.57) | MMP1MMP9MMP13ADAM17GFER | |
| SCHEMBL7315614 | 0.81 | MMP9 (0.86) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7318160 | 0.80 | MMP1 (0.85) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL27563881 | 0.80 | MMP1 (0.65) | MMP1MMP9MMP13ADAM17GFER | |
| SCHEMBL7448975 | 0.79 | MMP1 (1.00) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7325385 | 0.79 | MMP9 (1.00) | MMP1MMP9MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |