Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 6/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436647 | 1.00 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2PSMB5PSEN1 | |
| SCHEMBL7299047 | 0.95 | PSEN1 (0.44) | ALDH1A1HPGDSMN1; SMN2PSMB5PSEN1 | |
| SCHEMBL7444412 | 0.95 | PSEN1 (0.44) | ALDH1A1HPGDSMN1; SMN2PSMB5PSEN1 | |
| SCHEMBL7436642 | 0.88 | ALDH1A1 (0.42) | ALDH1A1HPGDSMN1; SMN2PSMB5REN | |
| SCHEMBL7301724 | 0.87 | PSMB5 (0.47) | PSMB5RENPSMB2PSMB1 | |
| SCHEMBL7301731 | 0.87 | PSMB5 (0.47) | PSMB5RENPSMB2PSMB1 | |
| SCHEMBL7301741 | 0.87 | PSMB5 (0.47) | PSMB5RENPSMB2PSMB1 | |
| SCHEMBL7437237 | 0.87 | CAPN1 (0.46) | REN | |
| SCHEMBL7437245 | 0.87 | CAPN1 (0.46) | REN | |
| SCHEMBL8681311 | 0.87 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2PSMB5PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |