Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341475 | 0.91 | F10 (0.42) | PPARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7311243 | 0.91 | F10 (0.42) | PPARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7311130 | 0.91 | F10 (0.42) | PPARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7333955 | 0.91 | F10 (0.42) | PPARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7319260 | 0.84 | F10 (0.41) | ACEALDH1A1MMEF10PRSS1 | |
| SCHEMBL7319399 | 0.82 | F10 (0.42) | F10PRSS1CTSBCTSLCTSK | |
| SCHEMBL7311722 | 0.78 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9AF10PRSS1 | |
| SCHEMBL6211555 | 0.76 | LMNA (0.41) | PPARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6211559 | 0.76 | LMNA (0.41) | PPARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7322605 | 0.76 | F10 (0.35) | ALDH1A1MAPTNPC1RAB9AF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | claimed |
| EP-0805817-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2001-08-16 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5866604-A | Thiol derivatives with metallopeptidase inhibitory activity | ZAMBON GROUP S.P.A. (IT) | 1999-02-02 | — | — | US | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |
| EP-0805817-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022998-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |