Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | MME | P08473 | 6/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311243 | 0.92 | F10 (0.42) | F10PRSS1F2MMEACE | |
| SCHEMBL7311130 | 0.92 | F10 (0.42) | F10PRSS1F2MMEACE | |
| SCHEMBL7333955 | 0.92 | F10 (0.42) | F10PRSS1F2MMEACE | |
| SCHEMBL7341475 | 0.92 | F10 (0.42) | F10PRSS1F2MMEACE | |
| SCHEMBL7314595 | 0.84 | PPARA (0.44) | F10PRSS1F2MMEACE | |
| SCHEMBL7319399 | 0.83 | F10 (0.42) | F10PRSS1F2CTSLCTSB | |
| SCHEMBL7311722 | 0.80 | ALDH1A1 (0.36) | F10PRSS1F2ALDH1A1CTSL | |
| SCHEMBL7316837 | 0.80 | PTGES (0.43) | F10PRSS1F2ALDH1A1 | |
| SCHEMBL7322605 | 0.79 | F10 (0.35) | F10PRSS1F2ALDH1A1 | |
| SCHEMBL6211559 | 0.78 | LMNA (0.41) | F10PRSS1F2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805817-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2001-08-16 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5866604-A | Thiol derivatives with metallopeptidase inhibitory activity | ZAMBON GROUP S.P.A. (IT) | 1999-02-02 | — | — | US | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |