Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314903 | 0.85 | ALOX15 (0.54) | PDE4APDE4BPDE4DPDE4C | |
| Hydrochloric Acid SCHEMBL7387770 | 0.84 | ALOX15 (0.53) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL6889304 | 0.83 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE4C | |
| Hydrochloric Acid SCHEMBL6887553 | 0.82 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8436326 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7321228 | 0.80 | PDE4B (0.49) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1389001 | 0.80 | PDE4A (0.49) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1157626 | 0.80 | POLB (0.48) | PDE4APDE4BPDE4DPDE4CSLC5A7 | |
| SCHEMBL7317449 | 0.78 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4CSLC5A7 | |
| SCHEMBL6881979 | 0.78 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640065-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2001-10-17 | — | — | EP | disclosed |
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |