Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17439398 | 0.85 | PDK2 (0.64) | PDK2SLC6A3KMT2AGAAMEN1 | |
| SCHEMBL7324013 | 0.85 | PDK2 (0.60) | PDK2KMT2AGAAMEN1CA4 | |
| SCHEMBL17456241 | 0.85 | PDK2 (0.52) | PDK2SLC6A3SLC6A2SLC6A4KMT2A | |
| SCHEMBL14970799 | 0.85 | PDK2 (0.49) | PDK2SLC6A3KMT2AMEN1MAPT | |
| SCHEMBL17471968 | 0.85 | PDK2 (0.59) | PDK2SLC6A3SLC6A2SLC6A4KMT2A | |
| SCHEMBL19039047 | 0.84 | PDK2 (0.50) | PDK2KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL30281291 | 0.84 | PDK2 (0.50) | PDK2KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL13185281 | 0.83 | PDK2 (0.55) | PDK2SLC6A3SLC6A2SLC6A4KMT2A | |
| SCHEMBL22875765 | 0.81 | PDK2 (0.54) | PDK2CA1CA2 | |
| SCHEMBL30873770 | 0.81 | MAPT (0.57) | PDK2SLC6A3SLC6A2SLC6A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |
| US-5447960-A | Fungicidal use of phenolic aromatic compounds | DOWELANCO (US) | 1995-09-05 | — | — | US | disclosed |