SCHEMBL7315137

SCHEMBL7315137

COc1ccc(S(=O)(=O)N(Cc2ccccc2)c2c(C(=O)O)cc(OC)c(OC)c2OC)cc1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 14/20 0.62
MMP13 P45452 13/20 0.62
MMP1 P03956 12/20 0.62
ADAM17 P78536 2/20 0.55
NR3C1 P04150 1/20 0.54
PGR P06401 1/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
PTGES O14684 1/20 0.53
TAS2R14 Q9NYV8 1/20 0.53
TAS2R8 Q9NYW2 1/20 0.53
CXCR3 P49682 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7322924 0.92 MMP9 (0.62) MMP9MMP13MMP1ADAM17NR3C1
SCHEMBL7448605 0.90 MMP13 (0.77) MMP9MMP13MMP1ADAM17
SCHEMBL7445098 0.90 MMP9 (0.64) MMP9MMP13MMP1ADAM17
SCHEMBL7322655 0.85 MMP13 (0.83) MMP9MMP13MMP1ADAM17ALDH1A1
SCHEMBL7318672 0.84 MMP13 (0.71) MMP9MMP13MMP1ADAM17ALDH1A1
SCHEMBL7322979 0.84 MMP13 (0.68) MMP9MMP13MMP1ADAM17ALDH1A1
SCHEMBL7317808 0.84 MMP9 (0.81) MMP9MMP13MMP1ADAM17NR3C1
SCHEMBL7313461 0.82 MMP13 (0.81) MMP9MMP13MMP1ADAM17ALDH1A1
SCHEMBL27510662 0.82 MMP13 (0.65) MMP9MMP13MMP1ADAM17ALDH1A1
SCHEMBL7506961 0.81 MMP9 (0.68) MMP9MMP13MMP1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed