Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 18/20 | 0.46 |
| ▸ | MMP13 | P45452 | 18/20 | 0.46 |
| ▸ | MMP1 | P03956 | 17/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313738 | 0.92 | NAMPT (0.43) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7316354 | 0.91 | NAMPT (0.42) | MMP9MMP13MMP1NAMPTPOLB | |
| SCHEMBL7324868 | 0.89 | MMP9 (0.50) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7320609 | 0.88 | MMP9 (0.49) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7318793 | 0.87 | MMP9 (0.53) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7319364 | 0.81 | MMP9 (0.54) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7315622 | 0.81 | MMP13 (0.46) | MMP9MMP13MMP1ADAM17POLB | |
| SCHEMBL7316691 | 0.81 | MMP13 (0.48) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7318942 | 0.81 | MMP13 (0.52) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7317531 | 0.81 | NAMPT (0.47) | MMP9MMP13MMP1ADAM17NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |