Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404242 | 0.87 | RXFP1 (0.53) | RXFP1MAPTNPSR1PKMTP53 | |
| SCHEMBL9404501 | 0.85 | RXFP1 (0.53) | RXFP1MAPTNPSR1PKMTP53 | |
| SCHEMBL7320310 | 0.85 | RXFP1 (0.53) | RXFP1MAPTNPSR1PKMTP53 | |
| SCHEMBL9404284 | 0.83 | RXFP1 (0.49) | RXFP1MAPTTP53POLBKDM4E | |
| SCHEMBL9404296 | 0.77 | HTT (0.44) | RXFP1MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL18394497 | 0.74 | ALDH1A1 (0.58) | RXFP1MAPTNPSR1POLBKDM4E | |
| SCHEMBL9404376 | 0.72 | HTT (0.58) | RXFP1MAPTNPSR1TP53POLB | |
| SCHEMBL8712545 | 0.71 | RXFP1 (0.54) | RXFP1MAPTNPSR1PKMTP53 | |
| SCHEMBL18394513 | 0.70 | PTGS1 (0.56) | RXFP1MAPTKDM4EALDH1A1MTOR | |
| SCHEMBL14322737 | 0.70 | RXFP1 (0.52) | RXFP1TP53POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535104-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1996-09-04 | — | — | EP | claimed |
| EP-0535104-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1996-09-04 | — | — | EP | disclosed |
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| US-5276028-A | Psychological disorders, anticonvulsants, anxiolytic or hypnotics and cognition activators | NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0535104-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000298-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-09 | — | — | WO | disclosed |