Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 9/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320310 | 0.89 | RXFP1 (0.53) | RXFP1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL9404393 | 0.85 | ABL1 (0.40) | RXFP1KDM4EALDH1A1L3MBTL1POLB | |
| SCHEMBL7315229 | 0.85 | RXFP1 (0.69) | RXFP1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL9404242 | 0.81 | RXFP1 (0.53) | RXFP1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL9430096 | 0.74 | MTOR (0.43) | RXFP1MAPTMTORPOLBPIK3CA | |
| SCHEMBL9312142 | 0.73 | POLB (0.40) | RXFP1KDM4EPOLBPIK3CA | |
| SCHEMBL9430489 | 0.69 | LRRK2 (0.39) | ALDH1A1MAPTMTORTP53POLB | |
| SCHEMBL18394497 | 0.69 | ALDH1A1 (0.58) | RXFP1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL9404286 | 0.69 | GABRA1 (0.48) | — | |
| SCHEMBL9404451 | 0.69 | OPRK1 (0.37) | KDM4EALDH1A1POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |