Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322024 | 0.79 | KDM4E (0.44) | HSD17B10HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL7322029 | 0.79 | KDM4E (0.44) | HSD17B10HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL4982611 | 0.79 | HSD17B10 (0.59) | HSD17B10HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL18297695 | 0.78 | PSIP1 (0.43) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11511266 | 0.78 | HSD17B10 (0.53) | HSD17B10HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL4529804 | 0.75 | BACE1 (0.51) | HSD17B10HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL16856424 | 0.75 | HSD17B10 (0.50) | HSD17B10HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL12427631 | 0.74 | PLK1 (0.67) | HSD17B10HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL875144 | 0.74 | HSD17B10 (0.58) | HSD17B10LMNAKMT2AKDM4EHPGD | |
| SCHEMBL10055034 | 0.73 | HDAC1 (0.54) | HSD17B10HDAC1HDAC8HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207701-B1 | AS ANTI-ANGIOGENIC, ANTI-ARTHRITIC, ANTI-INFLAMMATORY, ANTI-RETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC AGENTS | ABBOTT LABORATORIES | 2001-03-27 | — | — | US | disclosed |