Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.48 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.48 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.48 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272345 | 0.89 | PARP10 (0.58) | MMP13HPGDMAPTRAB9AALDH1A1 | |
| SCHEMBL9786679 | 0.89 | PARP10 (0.58) | MMP13HPGDMAPTRAB9AALDH1A1 | |
| SCHEMBL5637913 | 0.87 | ALDH1A1 (0.62) | HPGDMAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2310 | 0.87 | ALDH1A1 (0.62) | HPGDMAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11763162 | 0.86 | ACHE (0.60) | HPGDMAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL20836631 | 0.83 | HPGD (0.79) | MMP13HPGDMAPTRAB9AALDH1A1 | |
| SCHEMBL11511850 | 0.83 | PARP10 (0.66) | HPGDMAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL24087885 | 0.83 | ALDH1A1 (0.73) | MMP13HPGDMAPTRAB9AALDH1A1 | |
| SCHEMBL10084164 | 0.83 | ALDH1A1 (0.73) | MMP13HPGDMAPTRAB9AALDH1A1 | |
| SCHEMBL16997316 | 0.83 | ALDH1A1 (0.73) | MMP13HPGDMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805813-B1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID CO (US) | 2002-05-15 | — | — | EP | disclosed |
| CN-1052725-C | Tricyclic vasopressin antagonists | AMERICAN CYANAMID CO (US) | 2000-05-24 | — | — | CN | disclosed |
| US-5780471-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| CN-1178532-A | Tricyclic vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-04-08 | — | — | CN | disclosed |
| WO-1996022292-A1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5521173-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| US-4161529-A | Phenoxy phenyl pyrrolidine compounds, compositions and methods of use | SCIENCE UNION ET CIE, SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) | 1979-07-17 | — | — | US | disclosed |