Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368230 | 0.92 | ABCB1 (0.48) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL10368228 | 0.92 | ABCB1 (0.48) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL10368511 | 0.89 | ABCB1 (0.46) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL7317593 | 0.89 | ABCB1 (0.51) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL7319281 | 0.87 | ADORA3 (0.47) | ABCB1ADRA1AADRA2AADORA3CHRM2 | |
| SCHEMBL7311935 | 0.87 | KCNH2 (0.48) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL7316659 | 0.86 | MAPT (0.60) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL10998252 | 0.84 | MAPT (0.57) | ABCB1MAPTADRA1AHIF1AMEN1 | |
| SCHEMBL10998756 | 0.84 | MAPT (0.62) | ABCB1MAPTHIF1AMEN1CYP1A2 | |
| SCHEMBL7313818 | 0.83 | ADRA2A (0.45) | ABCB1ADRA1AKMT2AADRA2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177965-B1 | NOVEL OXA- AND THIADIAZOLYL DERIVATIVES AND THEIR USE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-03-21 | — | — | EP | claimed |
| US-4705786-A | Novel oxadiazolyl-1,4-dihydropyridines useful as antihypertensive agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-11-10 | — | — | US | claimed |
| EP-0177965-A2 | Novel oxa- and thiadiazolyl derivatives and their use | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1986-04-16 | — | — | EP | claimed |