Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366138 | 0.91 | CACNA1F (0.41) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10367252 | 0.88 | CACNA1F (0.38) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7319281 | 0.87 | ADORA3 (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7315909 | 0.83 | ABCB1 (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10367146 | 0.78 | MEN1 (0.37) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL10992175 | 0.78 | CYP3A4 (0.42) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL10367338 | 0.75 | ADORA3 (0.34) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL10368230 | 0.74 | ABCB1 (0.48) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10368228 | 0.74 | ABCB1 (0.48) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7317593 | 0.73 | ABCB1 (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177965-B1 | NOVEL OXA- AND THIADIAZOLYL DERIVATIVES AND THEIR USE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-03-21 | — | — | EP | claimed |
| US-4705786-A | Novel oxadiazolyl-1,4-dihydropyridines useful as antihypertensive agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-11-10 | — | — | US | claimed |
| EP-0177965-A2 | Novel oxa- and thiadiazolyl derivatives and their use | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1986-04-16 | — | — | EP | claimed |