Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 6/20 | 0.37 |
| ▸ | CTSS | P25774 | 6/20 | 0.37 |
| ▸ | CTSL | P07711 | 4/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316104 | 1.00 | CYP11B1 (0.39) | CYP11B1CYP11B2CTSKCTSSCTSL | |
| SCHEMBL7316105 | 1.00 | CYP11B1 (0.39) | CYP11B1CYP11B2CTSKCTSSCTSL | |
| SCHEMBL7320000 | 0.82 | CA1 (0.36) | CYP11B1CYP11B2CYP1A2CYP3A4GABRA1 | |
| SCHEMBL7313899 | 0.80 | CTSK (0.42) | CYP11B1CYP11B2CTSKCTSSCTSL | |
| SCHEMBL7313914 | 0.80 | CTSK (0.42) | CYP11B1CYP11B2CTSKCTSSCTSL | |
| Hydrochloric Acid SCHEMBL7285811 | 0.76 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP1A2CYP3A4GABRA1 | |
| SCHEMBL7369511 | 0.76 | CYP11B1 (0.38) | CYP11B1CYP11B2PSMB5CYP1A2CYP3A4 | |
| SCHEMBL3712784 | 0.76 | ACE2 (0.39) | CYP11B1CYP11B2CTSKCTSSCTSL | |
| SCHEMBL8249276 | 0.72 | ACE2 (0.60) | CYP11B1CYP11B2CTSK | |
| SCHEMBL1658524 | 0.72 | ACE2 (0.60) | CYP11B1CYP11B2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |