Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316105 | 0.82 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7316112 | 0.82 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7316104 | 0.82 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7314797 | 0.80 | MAPT (0.41) | LNPEPKMT2ACYP1A2CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL7285811 | 0.77 | CYP11B1 (0.43) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL3712784 | 0.74 | ACE2 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL7313914 | 0.72 | CTSK (0.42) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7313899 | 0.72 | CTSK (0.42) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7369511 | 0.72 | CYP11B1 (0.38) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL22850232 | 0.71 | CYP11B1 (0.42) | CYP11B1CYP11B2SLC1A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |