Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.36 |
| ▸ | SELP | P16109 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316193 | 1.00 | MAP3K7 (0.36) | MAP3K7TAB1SELPNR4A2CYP2C19 | |
| SCHEMBL7316533 | 0.67 | ALDH1A1 (0.39) | NR4A2CYP2C19HSD17B10NPC1ALDH1A1 | |
| SCHEMBL3953444 | 0.65 | NR4A2 (0.38) | MAP3K7TAB1NR4A2APP | |
| SCHEMBL5870589 | 0.64 | CYP2C19 (0.65) | CYP2C19HSD17B10NPC1ALDH1A1MAPT | |
| SCHEMBL7322217 | 0.64 | MAP3K7 (0.37) | MAP3K7TAB1NR4A2APP | |
| SCHEMBL3003194 | 0.64 | MAP3K7 (0.37) | MAP3K7TAB1NR4A2APP | |
| SCHEMBL6499135 | 0.63 | CYP2C19 (0.44) | CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL5870372 | 0.63 | CYP2C19 (0.44) | CYP2C19HSD17B10ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5869997 | 0.63 | CYP2C19 (0.62) | CYP2C19HSD17B10NPC1ALDH1A1MAPT | |
| SCHEMBL24149480 | 0.62 | NR4A2 (0.41) | MAP3K7TAB1NR4A2APPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242973-B1 | INDOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1991-07-17 | — | — | EP | disclosed |
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0242973-A1 | Indole derivatives, method for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-10-28 | — | — | EP | disclosed |