Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312464 | 0.93 | MEN1 (0.48) | HSP90AA1AVPR2GPR27MEN1KMT2A | |
| SCHEMBL7319110 | 0.88 | HSP90AA1 (0.46) | HSP90AA1AVPR2GPR27MEN1KMT2A | |
| SCHEMBL7321962 | 0.83 | HSP90AA1 (0.47) | HSP90AA1MEN1KMT2AALDH1A1MTNR1A | |
| SCHEMBL7317403 | 0.82 | METAP2 (0.48) | HSP90AA1MEN1KMT2AALDH1A1MTNR1A | |
| SCHEMBL7318301 | 0.82 | MTNR1A (0.43) | HSP90AA1MEN1KMT2AALDH1A1MTNR1A | |
| SCHEMBL7351226 | 0.81 | MEN1 (0.48) | HSP90AA1AVPR2GPR27MEN1KMT2A | |
| SCHEMBL7316525 | 0.81 | ALDH1A1 (0.42) | HSP90AA1MEN1KMT2AALDH1A1MTNR1A | |
| SCHEMBL7313794 | 0.81 | MTNR1A (0.42) | HSP90AA1AVPR2GPR27MEN1KMT2A | |
| SCHEMBL7323187 | 0.80 | MTNR1A (0.48) | MEN1KMT2AALDH1A1MTNR1AMTNR1B | |
| SCHEMBL7321197 | 0.80 | MTNR1A (0.41) | HSP90AA1MEN1KMT2AALDH1A1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |