SCHEMBL7316304

SCHEMBL7316304

COC(=O)c1cccc(NC(=O)c2ccc([N+](=O)[O-])cc2)c1N

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.57
MAPT P10636 2/20 0.57
KDM4E B2RXH2 1/20 0.57
NPC1 O15118 1/20 0.55
MEN1 O00255 4/20 0.52
KMT2A Q03164 4/20 0.52
POLB P06746 1/20 0.52
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
TSHR P16473 1/20 0.51
CYP2C19 P33261 1/20 0.51
KDR P35968 1/20 0.51
DUSP3 P51452 1/20 0.51
PTPN5 P54829 1/20 0.51
CASP6 P55212 1/20 0.51
PTPN11 Q06124 1/20 0.51
LMNA P02545 1/20 0.51
SNCA P37840 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.50
RXFP1 Q9HBX9 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6709802 0.87 TSHR (0.67) ALDH1A1MAPTKDM4ENPC1MEN1
SCHEMBL7318242 0.84 TSHR (0.58) ALDH1A1MAPTKDM4ENPC1MEN1
SCHEMBL7311425 0.83 TSHR (0.59) ALDH1A1MAPTKDM4EMEN1KMT2A
SCHEMBL8372144 0.83 NPC1 (0.50) ALDH1A1MAPTKDM4ENPC1MEN1
SCHEMBL7315643 0.82 HDAC1 (0.64) ALDH1A1MAPTKDM4ENPC1MEN1
SCHEMBL505634 0.81 PDCD1 (0.60) MAPTKDM4ENPC1MEN1KMT2A
SCHEMBL7323880 0.80 PTGS1 (0.59) KDM4EKMT2ACYP1A2CYP2D6TSHR
SCHEMBL7318284 0.79 RXFP1 (0.57) ALDH1A1MAPTKDM4EMEN1KMT2A
SCHEMBL7028470 0.79 NPC1 (0.56) ALDH1A1MAPTKDM4ENPC1MEN1
SCHEMBL18255503 0.78 RAB9A (0.64) ALDH1A1MAPTKDM4ENPC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0841924-B1 BENZIMIDAZOLE COMPOUNDS UNIV NEWCASTLE VENTURES LTD (GB) 2002-10-02 EP disclosed
US-6310082-B1 PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE POLY(ADP-RIBOSE)POLYMERASE ENZYME INHIBITING AMOUNT OF BENZIMIDAZOLE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PRO-DRUG FORM THEREOF, WITH ACCEPTABLE CARRIER NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 2001-10-30 US disclosed
US-6100283-A PRODRUG PHOSPHATE DERIVATIVE FOR POLY (ADP-RIBOSE) POLYMERASE ENZYME INHIBITOR FOR ADMINISTERING IN CONJUNCTION WITH ANTITUMOR DRUG OR RADIOTHERAPY NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 2000-08-08 US disclosed
EP-0841924-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1998-05-20 EP disclosed
WO-1997004771-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1997-02-13 WO disclosed