Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.61 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ELANE | P08246 | 1/20 | 0.58 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367856 | 0.87 | LMNA (0.70) | TSHRNPC1MAPTALDH1A1MEN1 | |
| SCHEMBL7316304 | 0.87 | ALDH1A1 (0.57) | TSHRCYP1A2CYP2D6CYP2C19NPC1 | |
| SCHEMBL7372951 | 0.86 | KMT2A (0.69) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4094329 | 0.86 | KMT2A (0.66) | TSHRNPC1MAPTALDH1A1MEN1 | |
| SCHEMBL1309081 | 0.85 | SMN1; SMN2 (0.70) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11665959 | 0.82 | TSHR (0.77) | TSHRCYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL7374064 | 0.82 | MEN1 (0.78) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6716445 | 0.82 | ALDH1A1 (0.60) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4443911 | 0.82 | ALOX5 (0.63) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9339256 | 0.81 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004022525-A1 | AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | claimed |
| WO-2004022525-A1 | AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |