SCHEMBL7315643

SCHEMBL7315643

COC(=O)c1cccc(NC(=O)c2ccc(OC)cc2)c1N

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.64
HDAC3 O15379 1/20 0.64
HDAC4 P56524 1/20 0.64
HDAC7 Q8WUI4 1/20 0.64
HDAC2 Q92769 1/20 0.64
HDAC10 Q969S8 1/20 0.64
HDAC11 Q96DB2 1/20 0.64
HDAC8 Q9BY41 1/20 0.64
HDAC6 Q9UBN7 1/20 0.64
HDAC9 Q9UKV0 1/20 0.64
HDAC5 Q9UQL6 1/20 0.64
F10 P00742 2/20 0.64
KDM4E B2RXH2 3/20 0.60
ALDH1A1 P00352 3/20 0.60
HPGD P15428 2/20 0.60
POLB P06746 2/20 0.60
NPC1 O15118 5/20 0.58
KMT2A Q03164 4/20 0.58
RAB9A P51151 3/20 0.58
TSHR P16473 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7318242 0.89 TSHR (0.58) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL7311425 0.87 TSHR (0.59) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL18255503 0.87 RAB9A (0.64) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL7314121 0.87 MEN1 (0.68) KDM4EALDH1A1HPGDPOLBNPC1
SCHEMBL11045073 0.86 F10 (0.77) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL505634 0.85 PDCD1 (0.60) HDAC1HDAC3HDAC2KDM4EHPGD
SCHEMBL18255505 0.84 TSHR (0.51) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL7323880 0.84 PTGS1 (0.59) HDAC1KDM4EHPGDKMT2ATSHR
SCHEMBL7318284 0.83 RXFP1 (0.57) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL7316304 0.82 ALDH1A1 (0.57) HDAC1HDAC6KDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0841924-B1 BENZIMIDAZOLE COMPOUNDS UNIV NEWCASTLE VENTURES LTD (GB) 2002-10-02 EP disclosed
US-6310082-B1 PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE POLY(ADP-RIBOSE)POLYMERASE ENZYME INHIBITING AMOUNT OF BENZIMIDAZOLE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PRO-DRUG FORM THEREOF, WITH ACCEPTABLE CARRIER NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 2001-10-30 US disclosed
US-6100283-A PRODRUG PHOSPHATE DERIVATIVE FOR POLY (ADP-RIBOSE) POLYMERASE ENZYME INHIBITOR FOR ADMINISTERING IN CONJUNCTION WITH ANTITUMOR DRUG OR RADIOTHERAPY NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 2000-08-08 US disclosed
EP-0841924-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1998-05-20 EP disclosed
WO-1997004771-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1997-02-13 WO disclosed