SCHEMBL7316358

SCHEMBL7316358

COc1ccc(S(=O)(=O)N(Cc2ccccc2)c2c(C)ccc(C)c2C=O)cc1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.62
ALDH1A1 P00352 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
MMP9 P14780 11/20 0.61
MMP13 P45452 11/20 0.61
MMP1 P03956 10/20 0.61
NR3C1 P04150 1/20 0.59
PGR P06401 1/20 0.59
CNR1 P21554 2/20 0.53
CNR2 P34972 2/20 0.53
PTGES O14684 1/20 0.52
TAS2R14 Q9NYV8 1/20 0.52
TAS2R8 Q9NYW2 1/20 0.52
CXCR3 P49682 1/20 0.52
ADAM17 P78536 2/20 0.52
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7316552 0.87 MMP9 (0.65) MMP9MMP13MMP1ADAM17
SCHEMBL7322409 0.85 MMP9 (0.66) LMNAALDH1A1NPSR1MMP9MMP13
SCHEMBL7319282 0.83 MMP9 (0.63) LMNAALDH1A1NPSR1MMP9MMP13
SCHEMBL7313461 0.82 MMP13 (0.81) LMNAALDH1A1NPSR1MMP9MMP13
SCHEMBL6559734 0.80 MMP9 (0.81) LMNAALDH1A1NPSR1MMP9MMP13
SCHEMBL7316160 0.79 MMP9 (0.76) MMP9MMP13MMP1ADAM17
SCHEMBL7322655 0.79 MMP13 (0.83) LMNAALDH1A1NPSR1MMP9MMP13
SCHEMBL7323418 0.78 MMP9 (0.61) LMNAALDH1A1NPSR1MMP9MMP13
SCHEMBL7321201 0.78 MMP13 (0.66) MMP9MMP13MMP1ADAM17
SCHEMBL7318672 0.78 MMP13 (0.71) LMNAALDH1A1NPSR1MMP9MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed