SCHEMBL7316505

SCHEMBL7316505

Cc1ccc(Sc2ccc(C(=O)O)cc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.74
SMN1; SMN2 Q16637 2/20 0.74
SRD5A2 P31213 3/20 0.65
LMNA P02545 3/20 0.56
HPGD P15428 2/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
TP53 P04637 1/20 0.52
TSHR P16473 1/20 0.52
RXRA P19793 3/20 0.51
RXRB P28702 3/20 0.51
RXRG P48443 2/20 0.51
RARB P10826 1/20 0.51
RARG P13631 1/20 0.51
CES2 O00748 2/20 0.50
CES1 P23141 2/20 0.50
KDM4E B2RXH2 2/20 0.49
P2RY14 Q15391 1/20 0.48
GAA P10253 1/20 0.47
APEX1 P27695 1/20 0.47
GFER P55789 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15220060 0.89 TSHR (0.67) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
SCHEMBL71112 0.89 TSHR (0.67) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
SCHEMBL15220063 0.89 TSHR (0.67) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
SCHEMBL20615020 0.87 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
Barium SCHEMBL9452526 0.86 TSHR (0.63) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
Hydrochloric Acid SCHEMBL7138094 0.86 TSHR (0.63) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
SCHEMBL9459884 0.86 TSHR (0.63) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
4-Methylbenzoic Acid SCHEMBL93638 0.86 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
Terephthalic Acid SCHEMBL526449 0.86 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD
4-Methylbenzoic Acid SCHEMBL11366477 0.86 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805813-B1 TRICYCLIC VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID CO (US) 2002-05-15 EP disclosed
US-5780471-A Tricyclic benzazepine vasopressin antagonists AMERICAN CYANAMID COMPANY (US) 1998-07-14 US disclosed
US-5521173-A TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-28 US disclosed