Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323404 | 1.00 | AKR1C3 (0.58) | AKR1C3LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL8364333 | 0.95 | AKR1C3 (0.53) | AKR1C3LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL8366229 | 0.95 | AKR1C3 (0.53) | AKR1C3LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL8366252 | 0.92 | AKR1C3 (0.52) | AKR1C3LMNAMEN1KMT2AKDM1A | |
| SCHEMBL7320733 | 0.88 | DRD3 (0.61) | — | |
| SCHEMBL7322835 | 0.85 | MEN1 (0.58) | AKR1C3LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL27702845 | 0.84 | KDM1A (0.65) | AKR1C3LMNAMEN1KMT2AKDM1A | |
| SCHEMBL8366277 | 0.83 | MEN1 (0.49) | AKR1C3MEN1KMT2AKDM1AMAOA | |
| SCHEMBL7311403 | 0.81 | AKR1C3 (0.85) | AKR1C3LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8697170 | 0.81 | MEN1 (0.56) | AKR1C3LMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612378-A | TREATING THROMBOSIS, ISCHEMIA, STROKE, RESTENOSIS OR INFLAMMATION | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996039380-A1 | BIS-ARYLSULFONYLAMINOBENZAMIDE DERIVATIVES AND THE USE THEREOF AS FACTOR Xa INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |